Types of spectrum antibiotics
NARROW SPECTRUM AND EXTENDED BROAD SPECTRUM ANTIBIOTICS
NARROW SPECTRUM ANTIBIOTICS: Uses, Advantages & Disadvantages
INTRODUCTION:
Antibiotics may be defined as the sub-group of anti-infective that are derived from bacterial sources and are used to treat bacterial infections.
An antibiotic may be classified basically as "narrow-spectrum" or "broad-spectrum" depending on the range of bacterial types that it affects. Narrow-spectrum antibiotics are active against a selected group of bacterial types. Broad-spectrum antibiotics are active against a wider number of bacterial types and, thus, may be used to treat a variety of infectious diseases.1
USES OF NARROW SPECTRUM ANTIBIOTICS:2
Narrow spectrum antibiotics are used for the specific infection when the causative organism is known.
ADVANTAGES OF NARROW SPECTRUM ANTIBIOTICS:2
The narrow-spectrum antibiotic will not kill as many of the normal microorganisms in the body as the broad spectrum antibiotics. So, It has less ability to cause superinfection.The narrow spectrum antibiotic will cause less resistance of the bacteria as it will deal with only specific bacteria.DISADVANTAGES OF NARROW SPECTRUM ANTIBIOTICS:
Narrow spectrum antibiotics can be used only if the causative organism is identified.If you don't choose the drug very carefully, the drug may not actually kill the microorganism causing the infection.NARROW SPECTRUM ANTIBIOTICS:AzithromycinClarithromycinClindamycinErythromycinVancomycinAZITHROMYCIN:3
Azithromycin is a azalide, a subclass of macrolide antibiotic.
Indication:
Bacterial infections,those causing,middle ear infections,tonsillitis,throat infections,laryngitis,bronchitis,pneumonia,Typhoid,sinusitis.Urinary tract infectionsPresentation:
Presentation:
| Azithromycin | Dry Powder Suspension | 100mg |
| Azithromycin | Tablets | 250mg, 500mg |
| Azithromycin | Lyophilised Injection | 500mg |
CLARITHROMYCIN:4
Clarithromycin is a macrolide antibiotic which works by interfearing with the protein synthesis of the bacteria.
Indication:
- pharyngitis,
- tonsillitis,
- acute maxillary sinusitis,
- acute bacterial exacerbation of chronic bronchitis,
- pneumonia,
- skin structure infections
Presentation:
| Clarithromycin | Tablets | 250mg, 500mg |
CLINDAMYCIN:4
Clindamycin is lincosamine antibiotic.
Clindamycin has a bacteriostatic effect. It is a bacterial Protein synthesis inhibitor. It does so by binding preferentially to the 23S subunit of the bacterial 50s ribosome.
Indication:
- Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria, including infections of the respiratory tract, skin and soft tissue infections, and peritonitis
- In patients with hypersensitivity to penicillins, clindamycin may be used to treat infections caused by susceptible aerobic bacteria as well.
- It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus.
Presentation:
Presentation:
| Clarithromycin | Tablets | 250mg, 500mg |
CLINDAMYCIN:4
Clindamycin is lincosamine antibiotic.
Clindamycin has a bacteriostatic effect. It is a bacterial Protein synthesis inhibitor. It does so by binding preferentially to the 23S subunit of the bacterial 50s ribosome.
Indication:
- Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria, including infections of the respiratory tract, skin and soft tissue infections, and peritonitis
- In patients with hypersensitivity to penicillins, clindamycin may be used to treat infections caused by susceptible aerobic bacteria as well.
- It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus.
Presentation:
| Clindamycin | Injection | 300mg/2ml, 600mg/4ml |
| Clindamycin + Benzoyl Peroxide | Gel | 1% + 5% |
ERYTHROMYCIN:5
Erythromycin is a Macrolide antibiotic.
Mechanism Of Action:
Erythromycin is a bactericidal.Erythromycin inhibit protein synthesis by binding to the 23S rRNA molecule (in the 50S subunit) of the bacterial ribosome blocking the exit of the growing peptide chain of sensitive microorganisms.
Indication:
- Acute Bacterial Sinusitis,
- Acute Otitis Media Infection,
- Acute Streptococcal Pyogenes Bacterial Sinusitis,
- Acute Streptococcus Pneumoniae Bacterial Sinusitis,
- Bacterial Pneumonia,
- Chlamydia Cervicitis,
- Chlamydial Conjunctivitis,
- Chlamydia Trachomatis Urethritis,
- Diphtheria, Diphtheria Prevention,
- Listeriosis,
- Mycoplasmal Pneumonia,
- Neonatal Pneumonia,
- Nongonococcal Urethritis,
- Pertussis,
- Pharyngitis due to Streptococcus Pyogenes,
- Pneumococcal Pharyngitis
- Skin Infections
| Erythromycin | Tablets | 125mg, 250mg, 500mg |
VANCOMYCIN:3
Vancomycin is a glycopeptide antibiotic. Vancomycin is used for the treatment of infection caused by Gram-positive bacteria.
Vancomycin acts by inhibiting the bacterial cell wall synthesis.
Indication:
- Pseudomembranous enterocolitis caused by C. difficile,
- Serious MRSA Infection,
- Enterococcal endocarditis,
- Penicillin resistant pneumococcal infections,
- Infections caused by diphtheroids.
| Vancomycin | Lyophilised Injection | 500mg, 1g |
SRS PRODUCTS ON NARROW SPECTRUM ANTIBIOTICS:
| Active Ingrediant | Form | Strength | Pack Type | Packing Style |
Dry Powder Suspension | 100mg | Sachet | 10's | |
Azithromycin | Tablets | 250mg, 500mg | Blister | 10's |
Azithromycin | Lyophilised Injection | 500mg | Vial | 10ml Vial |
Tablets | 250mg, 500mg | Blister | 10's | |
Injection | 300mg/2ml, 600mg/4ml | Ampoule | 2ml, 4ml | |
Clindamycin + Benzoyl Peroxide | Gel | 1% +5% | Tube | 45g |
Tablets | 125mg, 250mg, 500mg | Blister | 10's | |
Lyophilised Injection | 500mg, 1g | Vial | 10ml, 20ml Vial |
Extended broad spectrum antibiotics
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